Exploring mitochondrial hydrogen sulfide signalling for therapeutic interventions in vascular diseases

Hydrogen sulfide (H2S), a gaseous signalling molecule, is important in numerous physiological and pathophysiological processes. Despite its initial identification as an environmental toxin, H2S now well described essential molecule that finely balanced to maintain cellular functions, especially modulating mitochondrial activity. Mitochondria are responsible for the oxidation of safe elimination while maintaining biogenesis. mitochondria generates various reactive sulfur species could post-translationally modify proteins by sulfhydration. Sulfhydrated participate many regulatory activities either direct interactions electron transport chain or indirect regulation epigenetics. These investigations explain importance research therapeutic beyond traditional understanding protective role through anti-inflammatory antioxidant properties. This review focuses on highlighting significant involvement pathway vascular diseases current donors use under development.